I would agree with most of the pointers that are mentioned above. When it comes to the discussion of clinical trials are ethically correct, one should also consider that for most people that are in unique situations where a new study for a solution is the only chance they have to get a cure/improvement in their overall health is substantial and at the same time their data can be used to further help humanity. The downside with clinical testing is that you have the risk of experiencing no improvement or can obtain additional unwanted side effects. This is where the informed consent is important to inform the patient with all information needed to make their decision. The other downside would be that health insurance will not cover side effects obtained from the study because it was essentially almost intentional. As mentioned before, all these tests have statistical supporting data to obtain probability of success and need to be approved by the IRB first. It all comes down of equivalent exchange and also playing with probability. With some patients this might be their only solution.